Diabetic retinopathy: Some people claim to see into the future…. But will our patients see in the future
- Diabetic retinopathy is a leading cause of preventable blindness in working age population.
- It is one of the most complex, multifactorial heterogenous disorder.
- Several factors influence development of an effective screening program such as screening method, population cover, cost and cost-effectiveness, guidelines, compliance, quality assurance. We need to make early screening more accessible.
- Future in screening: computer aided DR detection, automated identification of DR from color fundus image.
- Laser photocoagulation is effective treatment for PDR. The strongest evidence comes from two RCTs: Diabetic retinopathy study and early treatment study.
- Anti-VEGF treatment was approved by the FDA in 2012.
- Factors involved in angiogenesis and downstream signaling (PKC, angiopoietins, platelet-derived growth factor, Wnt signaling axis) and inflammatory cytokines are other target molecules.
The main challenge is the complex nature of the DR. Several new screening and treatment modalities are in the horizon.